To fix the Office "Something went wrong" error, restart your PC, launch the app in Safe Mode by holding Ctrl to disable add-ins, then run a Quick…
This is a catch-all error, which is exactly why it's annoying.
This is the highest-success fix and it almost never deletes your files or settings.
If a known bug is the cause, patches already exist.
Aggressive security suites sometimes block Office executables outright.
Read the complete breakdown, fixes and what happens next.